The 1918 to 1919 H1N1 Influenza Pandemic is among the most deadly events in recorded human history, having killed an estimated 50 to 100 million persons.
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In early 2009, a novel Pandemic H1N1 Influenza virus appeared, but it has not exhibited unusually high pathogenicity.
Recent H5N1 avian Influenza epizootics associated with sporadic human fatalities have heightened concern that a new Influenza pandemic, one at least as lethal as that of 1918, could be developing.
The 1918 to 1919 H1N1 Influenza Pandemic is among the most deadly events in recorded human history, having killed an estimated 50 to 100 million persons