Produs

Development of Controlled Release Three-Layered Diclofenac Tablet, Paperback/Arafat Mohammad

Name: Development of Controlled Release Three-Layered Diclofenac Tablet, Paperback/Arafat Mohammad
Brand: LAP Lambert Academic Publishing
SKU: ec2b492a12a019eab4c44fbd21aaf260
Price: 282.99 RON
Availability: InStock

Vânzător

elefant.ro

Cumpără

Pret

282.99 Lei

Categorie (vânzător)

Foreign Books

Marca

LAP Lambert Academic Publishing

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Preț: 282.99 Lei

Caracteristicile produsului Development of Controlled Release Three-Layered

Brand: LAP Lambert Academic Publishing
Categoria: Foreign Books
Magazin: elefant.ro
Ultima actualizare: 13-07-2026 00:25:33

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Descriere magazin:
Modified release dosage forms offer definite advantages over conventional release formulation of the same drug.The three-layered matrix system overcomes inherent disadvantages of non-linearity associated with the core, covered by two additional layers, each with different rates of swelling, gelling and erosion, is what accounts for the rate of drug release. When the tablet is first swallowed, the drug concentration is high but the surface area is small. As time goes by and the core swells, the surface area expands to compensate for the decrease in drug concentration. Based on these theoretical considerations the three-layered tablets were designed and Diclofenac Sodium, a weakly acidic drug and widely used NSAID, was taken as the model drug to evaluate the comparative release characteristics from different polymer matrices with different amount with the variation in the outer layers as well as in the core.Then the percent release from different batches of Diclofenac Sodium was plotted against time to get the zero order plots. In the zero order plots no true straight lines were obtained but statistically significant differences were found among the release profile.