Bipolar Depression Bipolar depressions are often intractable and potentially deadly.
The use of high doses of Thyroid hormone is recommended for Bipolar Depression in at least two major Treatment guidelines: the Texas Medication Algorithm Project for Bipolar I Depression and the Canadian/ISB.
We find from Kraepelin\'s lectures that Thyroid hormones have been in continuous use in psychiatry for at least 120 years, the oldest continuous Treatment in psychiatry with the exception of psychotherapy.
Bipolar Depression Bipolar depressions are often intractable and potentially deadly