Cancer is the second leading cause of mortality worldwide.
Most anticancerous natural products interfere with the initiation, development, and progression of Cancer b.
Many natural products have now been extensively researched, and numerous compounds have exhibited antiCancer and other beneficial actions in modern controlled studies.
However, it is only recently that researchers have begun to elucidate the mode of action of plant-derived agents at the molecular, cellular, and tissue level.
Dietary phytochemicals have many built-in advantages over synthetic compounds due to their proven safety, low cost, and oral bioavailability.
Phytotherapy (also called herbalism or herbal medicine) has provided remedies for ailments, including cancer, to the present day.
Consequently, development of new antiCancer agents with higher efficacy, selectivity, and little or no Side effects is an urgent goal.
Natural products, especially phytochemicals, have been used to help mankind sustain health since the dawn of medicine.
However, most cytotoxic drugs act on both cancerous and healthy cells and therefore elicit Side effects such as hair loss, bone marrow suppression, drug resistance, gastrointestinal lesions, neurologic dysfunction, and cardiac toxicity.
The most commonly used chemotherapy drugs are antimetabolites, DNA-interacting agents, antitubulin agents, hormones, and molecular targeting agents, all of which work to destroy cancerous cells or limit their proliferation.
Currently, the main Cancer treatment modalities are surgery, radiation-based therapy, chemotherapy, gene therapy, and/or hormonal therapy, either singly or in combination.
Many of these mutations alter the expression or activity of key gene products, caUsing unregulated cell division leading to cancer.
The risk factors may act singly or in concert to cause mutation of normal cells.
This rapid increase is due to both an aging and growing population, along with carcinogens, infections, genetic mutations, hormones, immune conditions, and the adoption of behavioral and dietary risk factors, such as smoking, unhealthy diet, physical inactivity, and environmental pollutants.
The occurrence of new Cancer cases is expected to grow by about 70% over the next two decades and estimated to reach over 15 million new cases diagnosed annually by the end of year 2020.
Over 10 million new patients are diagnosed with Cancer annually with over 6 million associated deaths, representing roughly 12% of worldwide mortality.
Cancer is the second leading cause of mortality worldwide
